Research Technician, MSI
ICID seeks to understand fundamental biological insights of cancer cells and opportunistic pathogens (bacterial, viral, and fungal) causing infection in immunocompromised patients, and to apply these insights to overcome these diseases through innovative strategies for detection, prevention, and therapeutic intervention.
Matthew Zimmerman’s research supports drug discovery programs focusing on viruses of pandemic concern (SARS-CoV-2 - Covid-19) and mycobacterial lung diseases. His laboratory uses mass spectrometry techniques to test newly discovered compounds to profile their drug metabolism and pharmacokinetic (DMPK) properties. Additionally, his team uses laser-capture microdissection to visualize the spatial distribution of drugs at the site of infection. This drug localization data is used to better understand drug efficacy in-vivo at a cellular level and to guide the development of new drugs and multi-drug regimens for the treatment of drug resistant tuberculosis.
The Center for Discovery and Innovation (CDI), was established by Hackensack Meridian Health (HMH) as an academic basic and translational research enterprise to rapidly translate science innovation to the clinic to improve outcomes for patients with cancer, infectious diseases, autoimmune disease and other acute and chronic diseases. The CDI has grown rapidly since its origins in 2019, and now has 18 labs, 150 scientists and support personnel, who are supported by more than 85 grants and contracts. Areas of expertise include genomics, epigenetics, drug resistance, stem cell biology, drug discovery, diagnostics and biomarker development, and pharmacology.
A day in the life of a Research Technician, MSI at Hackensack Meridian Health includes:
- Follows HPLC-MS/MS bioanalytical methods to quantify standard drugs and drug candidates in various biological samples to support pharmacokinetic studies (PK).
- Develops quantitative HPLC-MS/MS methods for the quantification of tuberculosis drugs.
- Uses laser capture microdissection and HPLC-MS/MS to define the quantitative spatial distribution of drugs in infected tissues and organs.
- Explores new methods and instrumentation to advance the field of bioanalytical HPLC-MS/MS analysis.
- Creates novel formulation strategies and makes routine drug formulations.
- Performs qualitative analysis of biological samples for identification of unknown drug metabolites and mechanism of action studies.
- Determines pharmacokinetic drug parameters using non-compartmental pharmacokinetics.
- Manages the lab and electronic records, maintains existing instruments, orders and set-up new instruments.
- Prepares reports and creates new report templates to document laboratory results.
- Other duties and/or projects as assigned.
- Adheres to the HMH Organizational competencies and standards of behavior.
Education, Knowledge, Skills and Abilities Required:
- Bachelors degree in biochemistry, chemistry, analytical chemistry or pharmacy.
- One (1) year of relevant laboratory experience.
- Hands on experience performing experiments or running assays in academic or professional lab.
- Excellent written and verbal communication skills.
- Proficient computer skills that may include but are not limited to Microsoft Office and/or Google Suite platforms.
Education, Knowledge, Skills and Abilities Preferred:
- Hands-on experience with the use of HPLC, LC-MS/MS (AB Sciex), and Orbitrap (Thermo Q-Exactive) based LC-MS systems.
- Knowledge of drug pharmacokinetics.
- Experience in handling biological samples.
- Two (2) years of experience operating mass spectrometry systems.
If you feel that the above description speaks directly to your strengths and capabilities, then please apply today!
Hackensack Meridian Health (HMH) is a Mandatory COVID-19 and Influenza Vaccination Facility
As a courtesy to assist you in your job search, we would like to send your resume to other areas of our Hackensack Meridian Health network who may have current openings that fit your skills and experience.