Postdoc Rsch Fllw, NeuroBio
The Postdoc Rsch Fllw, NeuroBio will work under the guidance of Dr. Vogel studying pediatric neuro-oncology, focusing on translational murine models of rare pediatric central nervous system (CNS) tumors. The research will seek to understand and test novel therapeutic approaches while partnering with industry to test and develop patient derived xenograft (PDX) models. The research done in our lab is closely partnered with patient treatment and the insights gained from the work will immediately translated into clinical approach and treatment strategies for the developing CNS (For details see Nature Medicine 18, 1797-1804 (2012)). Our lab employs a number of mouse genetic models with in vivo and in vitro systems to study tumorigenesis. These include novel subcellular imaging techniques, molecular/cellular neurobiology, protein biochemistry, genetic, and pharmacological methods. Our lab has a strong interest in translational neuroscience research and is focused on developing novel medical therapies in our models.
1. Design, develop, and test novel patient derived xenograft models for rare forms of pediatric central nervous system tumors.
2. Perform in vitro and in vivo molecular assays for tumor growth and treatment responses to novel therapeutics.
3. Confocal and advanced imaging techniques to determine tumorigenesis effects on the developing murine brain.
4. Design and conduct animal studies with tumor implantation and harvesting and processing of tissue for assays.
5. Perform data analysis and interpretation to interface with partners in industry to shape clinical approach and translated treatment to patients.
6. Present results in internal and external research forums such as Gordon Research Conference, Society for Neuroscience, Society for Neuro-Oncology. Presentations will be in the format of posters and talks with expectation of manuscript preparation.
7. Participate in grant and manuscript writing, as appropriate.
Education, Knowledge, Skills and Abilities Required:
1. Hold a Ph.D. or M.D./Ph.D. in neuroscience, genetics, developmental biology, molecular/cellular biology, regenerative biology, or biochemistry from an accredited graduate level institution.
2. Minimum publication or in preparation of two articles as first author in a reputable peer-reviewed scientific journal.
3. Excellent analytical and presentation skills.
Education, Knowledge, Skills and Abilities Preferred:
1. A strong background in biochemical, cellular, neuroscience, genetic, or developmental biology in mouse models.
2. Expertise in cell culture, cell engineering, flow cytometry, rodent handling, and basic cellular and molecular biology techniques required.
3. Show evidence of scientific productivity and writing skills, documented by authorship in publications.
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